The First Complete Human Paleogenome 255 2.1.4 Human and Neandertal Paleogenomics 255 2.2 the Black Death and Insights into Ancient Plagues 257 2.3 Reconstruction and Selection of Ancient Phenotypes 258 2.4 Epigenetics of Ancient Species 260
نویسندگان
چکیده
1 Reconstructing Paleogenomes 245 1.1 Ancient DNA 245 1.1.1 The Nature of Ancient DNA 245 1.1.2 The Common Effects of DNA Damage 246 1.2 The Recovery and Sequencing of Ancient DNA 246 1.2.1 Ancient DNA Extraction 246 1.2.2 DNA Library Preparation 247 1.2.3 Capture-Based Target Enrichment 248 1.2.4 Quantification of aDNA and Sequencing 249 1.3 Assembly and Analysis of a Paleogenome 250 1.3.1 Initial Data Processing 251 1.3.2 Mapping and Quality Control 252 1.3.3 Paleogenomic Analysis 253
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